Management of malaria

Drug treatment of uncomplicated malaria in adults
Plasmodium vivax, P. ovale, P. malariae, CQ-sensitive P. falciparumChloroquine:600 mg300 mg 6 hours later300 mg 24 hours later
300 mg 24 hours later
CQ-resistant, SP-sensitive P. falciparum Fansidar (SP): 3 tablets as single doseCQ- and SP-resistant P. falciparum Quinine: 600 mg 3 times daily for 7 days plus Tetracycline: 500 mg 4 times daily for 7 days or Fansidar (SP): 3 tablets as single dose
Alternative therapies
Mefloquine: 20 mg/kg in 2 doses 8 hours apart or Malarone: 4 tablets daily for 3 days or Coartemether: 4 tablets 12-hourly for 3 days or Lapdap (chlorproguanil/dapsone)
ollowing successful treatment of P. vivax or P. ovale malaria, it is necessary to give a 2- to 3-week course of primaquine (15 mg daily) to eradicate the hepatic hypnozoites and prevent relapse. This drug can precipitate haemolysis in patients with G6PD deficiency